The Upper Chartiers Creek Watershed includes the main population centers of Washington County with their urban and suburban residential areas.

The Watershed also includes extensive commercial and industrial development and the Arden Landfill.

More than 160 farm properties are enrolled in Agricultural Security Areas in Cecil, Chartiers, North Strabane, and Peters Townships, all townships that are entirely within the watershed. Additional farms are enrolled in other townships that are partly within watershed boundaries.